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| model features |
lung morphometry |
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| | > | | We use a system for evaluating lung component morphology, air space expansion and lung tissue destruction in vertical anisotropic tissue sections.
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| | > | | A computer-generated cycloid grid containing evenly spaced points and sine-wave cycloid lines, whose direction is perpendicular to the dorsoventral axis, is placed over the projections. For the measurement of air space expansion, intercepts of alveolar septa with the cycloid lines are counted, and a mean linear intercept of alveolar septa (Lm, in mm), the most commonly used morphometric indicator of emphysema, is calculated.
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| | > | | | To assess tissue loss, volume densities of lung components are measured by counting points of the grid that overlie alveolar septa (including alveolar walls juxtaposed to perivascular, peribronchiolar, or subpleural interstitium): alveolar air spaces including those containing inflammatory cells and other structures such as vessels and airways. |
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